For those engaged in a struggle against this modern-day epidemic, Physical Activity and Type 2 Diabetes provides cutting-edge research to energize current efforts in diabetes prevention, management, and treatment. The most in-depth and up-to-date book on the topic, Physical Activity and Type 2 Diabetes presents a series of independent but related chapters authored by the foremost researchers of insulin resistance examining topics such as these:
Physical inactivity as a primary cause for the rising incidence of insulin resistance
The emergence of an “exercise-deficient” phenotype
The effects of exercise training on selected aspects of substrate metabolism
The role of endurance and resistance training programs for the prevention and treatment of insulin resistance
The identification of new molecular targets and pathways useful for the treatment of insulin resistance and type 2 diabetes.
Part I: Aetiology of Insulin Resistance and Type 2 Diabetes: Prevalence and Consequences of the “Diabesity” Epidemic
Chapter 1: The Increasing Burden of Type 2 Diabetes: Magnitude, Causes, and Implications of the Epidemic
Chapter 2: Waging War on Type 2 Diabetes: Primary Prevention Through Exercise Biology
Part II: Defects in Metabolism and Insulin Resistance
Chapter 3: Fatty Acid Uptake and Insulin Resistance
Chapter 4: Lipid Metabolism and Insulin Signaling
Chapter 5: Metabolic Inflexibility and Insulin Resistance
Chapter 6: Nutrient Sensor Links Obesity With Diabetes Risk
Chapter 7: Inflammation-Induced Insulin Resistance in Obesity: When Immunity Affects Metabolic Control
Part III: Prevention of Type 2 Diabetes Through Exercise Training
Chapter 8: Transcription Factors Regulating Exercise Adaptation
Chapter 9: Exercise and Calorie Restriction Use Different Mechanisms to Improve Insulin Sensitivity
Chapter 10: Mitochondrial Oxidative Capacity and Insulin Resistance
Chapter 11: Effects of Acute Exercise and Exercise Training on Insulin Action in Skeletal Muscle
Chapter 12: Resistance Exercise Training and the Management of Diabetes
Part IV: Prevention of Type 2 Diabetes: Identification of Novel Molecular Targets and Pathways
Chapter 13: AMPK: The Master Switch for Type 2 Diabetes?
Chapter 14: Protein Kinase C and Insulin Resistance
Chapter 15: Evidence for the Prescription of Exercise as a Therapy for the Treatment of Patients With Type 2 Diabetes
John A. Hawley, PhD, is professor and head of the Exercise Metabolism and Diabetes Research Group in the School of Medical Sciences at the Royal Melbourne Institute of Technology in Melbourne, Australia, where he has a postgraduate research program comprising eight postdoctoral and doctoral students. His areas of research include the regulation of fat and carbohydrate metabolism, with a particular emphasis on insulin resistance and type 2 diabetes, and the role of exercise training in alleviating the metabolic syndrome.
Juleen R. Zierath, PhD, is professor of physiology and head of the section of integrative physiology in the department of surgical science, Karolinska Institutet, Stockholm, Sweden, and an adjunct professor of biochemistry at Boston University School of Medicine.