For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter).
The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features.
It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book.* And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and -they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint® presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies—animations, videos, and molecular models—all with voiceover narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well.
By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology.
PART I INTRODUCTION TO THE CELL
1. Cells and Genomes
2. Cell Chemistry and Biosynthesis
PART II BASIC GENETIC MECHANISMS
4. DNA, Chromosomes, and Genomes
5. DNA Replication, Repair, and Recombination
6. How Cells Read the Genome: From DNA to Protein
7. Control of Gene Expression
PART III METHODS
8. Manipulating Proteins, DNA, and RNA
9. Visualizing Cells
PART IV INTERNAL ORGANIZATION OF THE CELL
10. Membrane Structure
11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes
12. Intracellular Compartments and Protein Sorting
13. Intracellular Vesicular Traffic
14. Energy Conversion: Mitochondria and Chloroplasts
15. Mechanisms of Cell Communication 16. The Cytoskeleton
17. The Cell Cycle
18. Apoptosis PART V CELLS IN THEIR SOCIAL CONTEXT
19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix
20. Cancer Chapters
21–25 available on Media DVD-ROM:
21. Sexual Reproduction: Meiosis, Germ Cells, and Fertilization
22. Development of Multicellular Organisms
23. Specialized Tissues, Stem Cells, and Tissue Renewal
24. Pathogens, Infection, and Innate Immunity
25. The Adaptive Immune System
Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter